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  • This handout provides general information about diabetes mellitus in dogs. For information about its treatment, see the fact sheets "Diabetes Mellitus - Principles of Treatment" and "Diabetes Mellitus - Insulin Treatment".

  • Diabetes mellitus is caused by the failure of the pancreas to regulate blood sugar. In dogs, diabetes mellitus is usually Insulin Dependent Diabetes Mellitus (also called Type 2 Diabetes)

  • Diabetic ketoacidosis is a medical emergency that occurs when there is not enough insulin in the body to control blood sugar (glucose) levels. It is important for your veterinarian to perform appropriate tests in order to diagnose this disease as similar signs can occur with other medical conditions. Treatment involves hospitalization with IV fluids, short acting insulin and electrolyte replacement. The most important step in prevention is ensuring proper insulin dosing is being administered.

  • The diaphragm is the muscular partition that separates the abdomen and the chest. Tearing or disruption of this thin muscle is called a diaphragmatic hernia or diaphragmatic rupture. The most common cause of diaphragmatic hernia is blunt force trauma.

  • Diarrhea is a symptom of an underlying problem that may be minor or very serious. Some cases may resolve on their own or with minimal treatment, while other cases require in-depth diagnostic testing and more aggressive treatment to address the underlying condition. The possible causes, diagnostic tests, and treatment protocols for diarrhea in dogs are numerous and are explained in this handout.

  • If your dog is having diarrhea, please complete this questionnaire as accurately as possible before your appointment. This information will be very helpful to your veterinarian in determining the cause of diarrhea.

  • Diazepam is given by mouth, injection, or into the rectum and is used off label to treat anxiety, seizures, tense muscles, or decreased appetite. Give as directed by your veterinarian. Side effects include sleepiness, increased appetite, incoordination, weakness, agitation, drooling, and aggression. Do not give to cats by mouth, and do not use in pets that are allergic to it or other benzodiazepines, or in pets with severe liver disease. If a negative reaction occurs, please call your veterinary office.

  • Diazoxide is given by mouth and is used off label to treat low blood sugar associated with insulin-producing tumors of the pancreas. Give as directed by your veterinarian. Common side effects include drooling, lack of appetite, vomiting, and diarrhea. Do not use in pets that are allergic to it or thiazide diuretics, or in pets with low blood sugar due to anything other than a tumor. If a negative reaction occurs, please call your veterinary office.

  • Diclofenac ophthalmic is a topical nonsteroidal anti-inflammatory medication used to treat inflammatory eye conditions in cats, dogs, rabbits, avian species, and other animals. Diclofenac ophthalmic comes in liquid drop form.

  • Diethylstilbestrol is given by mouth and is used off label to treat urinary incontinence. Give as directed by your veterinarian. Side effects are uncommon when using a low dose, but may include mild vaginal spotting. It should not be used in pets that are allergic to it, in females with estrogen-sensitive tumors, in pets with anemia or low white blood cell counts, or in food production animals. If a negative reaction occurs, please call your veterinary office.