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  • Dinotefuran/permethrin/pyriproxyfen (brand name Vectra 3D®) is a topical (spot-on) antiparasitic drug that is applied directly to the skin. It is used to repel and kill fleas, ticks, mosquitoes, biting flies, sand flies, and biting/chewing lice in dogs and puppies that are at least 8 weeks of age and weigh at least 2.3 kg (5 lb). NEVER use in cats and avoid using in households with cats, if possible. Permethrin is poisonous to cats and any exposure may be fatal.

  • Dinotefuran/pyriproxyfen (brand name Vectra) is a topical (spot-on) antiparasitic drug used to repel and kill fleas in dogs and puppies that are at least 8 weeks of age and weigh at least 1.14 kg (2.5 lbs) and in cats and kittens that are at least 8 weeks of age and weigh at least 0.9 kg (2 lbs). Do not confuse this medication with Vectra 3D®, a similar product labeled for use in dogs only.

  • Diphenhydramine is given by mouth or as an injection and is used on and off label to treat allergic reactions, motion sickness, and to induce sedation. Side effects include sleepiness, and less commonly dry mouth and gastrointestinal upset.

  • Diphenoxylate + atropine (brand name Lomotil) is an opioid combination medication used to treat diarrhea or coughing in dogs and diarrhea in cats. Its use in cats is not generally recommended. Diphenoxylate + atropine is given by mouth in the form of a tablet or liquid. This article discusses administration, potential side effects, risks, and monitoring.

  • Discoid Lupus Erythematosus (DLE) is an autoimmune condition that causes skin sloughing particularly around the nose causing scabbing and erosions that can become infected with bacteria. It can also affect the ear flaps, genitals and rarely spread through the entire body. DLE is diagnosed by submitting skin biopsies of affected areas for histopathological analysis. As well as antibiotics to treat secondary bacterial infections, treatment involves suppression of the immune system including tacrolimus or steroid ointments/creams applied to the affected area. Some dogs will need tetracycline and niacinamide or stronger anti-inflammatories such as cyclosporine or corticosteroids. These treatments can be weaned once lesions resolve but flare-ups will likely occur, needing rechecks and repeat therapy. Sun exposure must be minimized as UV light can worsen the disease. If untreated, lesions can develop into squamous cell carcinoma.

  • Discospondylitis is a bacterial or fungal infection of the intervertebral disks and the adjacent vertebral bones. It primarily affects dogs, though rarely can affect cats. It affects large breed dogs more often and generally starts clinically as back pain. The diagnosis and treatment of this condition are outlined in this handout.

  • Dogs exhibit many normal behaviors that can seem unruly. Some dogs are overly active and never seem to settle. Attempts to stop disruptive, normal behaviors using corrections are not typically successful. Effective techniques rely on training desired responses instead. Sometimes, even when trained, dogs do not listen. This is usually due to a lack of understanding rather than deliberate disobedience. Retraining basic skills can be helpful.

  • Distemper virus is a highly contagious disease that can affect multiple body systems and is potentially fatal. Puppies are most susceptible, and respiratory, gastrointestinal, or neurologic signs may be seen. Vaccines are available and are highly effective at preventing disease.

  • A distichia (plural distichiae) is an eyelash that arises from an abnormal location on the eyelid or grows in an abnormal direction. Distichiae usually emerge along the margin of the eyelid through the duct or opening of the meibomian gland, although they may arise at other locations along the eyelid margins. The condition in which these abnormal eyelashes are found is called distichiasis.

  • DNA is a large complex molecule that carries the genetic information or genetic code of an organism. All common forms of life, such as viruses, bacteria, plants, and animals carry a copy of their own genetic code in each of their cells. Each organism has a unique section of DNA that is just like a fingerprint. DNA-PCR is often used to detect the presence of infectious organisms; especially when detecting extremely small numbers of infectious organisms and for detecting certain viruses and bacteria that are difficult to diagnose by other methods.